Interaction between chloroquine and indomethacin in airways smooth muscle in vivo
Identifieur interne : 003289 ( Main/Exploration ); précédent : 003288; suivant : 003290Interaction between chloroquine and indomethacin in airways smooth muscle in vivo
Auteurs : Arthur C. Sackeyfio [Ghana] ; Daniel K. Amankwaah [Ghana] ; Alhassan S. Yahaya [Ghana]Source :
- European Journal of Pharmacology [ 0014-2999 ] ; 1987.
English descriptors
- Teeft :
Abstract
Abstract: The indomethacin-induced enhancement of airways smooth muscle contractility to histamine reported earlier in vitro has now been demonstrated in conscious guinea-pigs. Chloroquine, an anti-malarial drug with phospholipase A2 inhibitory activity, antagonized histamine and also reversed the indomethacin-induced enhancement. These observations indicate that histamine-induced bronchospasm in vivo is modulated by the arachidonate system and that chloroquine-type phospholipase A2 inhibitors may ameliorate such bronchospasm. These findings also explain the observed clinical benefits of chloroquine in chronic asthmatics.
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DOI: 10.1016/0014-2999(87)90193-2
Affiliations:
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Yahaya</name><affiliation wicri:level="1"><country xml:lang="fr">Ghana</country><wicri:regionArea>Department of Pharmacology, Faculty of Pharmacy, University of Science and Technology, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Pharmacology</title><title level="j" type="abbrev">EJP</title><idno type="ISSN">0014-2999</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1987">1987</date><biblScope unit="volume">137</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="135">135</biblScope><biblScope unit="page" to="138">138</biblScope></imprint><idno type="ISSN">0014-2999</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0014-2999</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acetylcholine</term><term>Airway</term><term>Arachidonic</term><term>Bronchospasm</term><term>Chloroquine</term><term>Contractile</term><term>Enhancement</term><term>Histamine</term><term>Indomethacin</term><term>Krebs</term><term>Krebs solution</term><term>Lipoxygenase</term><term>Maximal response</term><term>Mepacrine</term><term>Pharmacol</term><term>Phospholipase</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The indomethacin-induced enhancement of airways smooth muscle contractility to histamine reported earlier in vitro has now been demonstrated in conscious guinea-pigs. Chloroquine, an anti-malarial drug with phospholipase A2 inhibitory activity, antagonized histamine and also reversed the indomethacin-induced enhancement. These observations indicate that histamine-induced bronchospasm in vivo is modulated by the arachidonate system and that chloroquine-type phospholipase A2 inhibitors may ameliorate such bronchospasm. These findings also explain the observed clinical benefits of chloroquine in chronic asthmatics.</div></front></TEI><affiliations><list><country><li>Ghana</li></country></list><tree><country name="Ghana"><noRegion><name sortKey="Sackeyfio, Arthur C" sort="Sackeyfio, Arthur C" uniqKey="Sackeyfio A" first="Arthur C." last="Sackeyfio">Arthur C. Sackeyfio</name></noRegion><name sortKey="Amankwaah, Daniel K" sort="Amankwaah, Daniel K" uniqKey="Amankwaah D" first="Daniel K." last="Amankwaah">Daniel K. Amankwaah</name><name sortKey="Yahaya, Alhassan S" sort="Yahaya, Alhassan S" uniqKey="Yahaya A" first="Alhassan S." last="Yahaya">Alhassan S. 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